For me, it would either be Batman and Alfred (yes, you read correctly: Alfred; even though Robin or Batgirl were great sidecicks, I feel it was Bruce Wayne’s inconspicuous butler that was his greatest strength, being not only his loyal valet, but also confidant, best friend, a voice of reason, especially during Batman’s early career, and finally, a father figure – and I think both of them can now be considered in-game characters thanks to the latter’s appearance in Arkham Origins) or Joel and Ellie from The Last of Us, going a long way from "I don’t like you, you don’t like me" to practically a father-daughter relantionship. At least, those are the two couples that came to me instantaneously. What would be your choices?
Oh, if similar thread already exists, I’m sorry – I did seach, honestly.
Anyway, Sonic and Tails is one of them.
Ico and Yorda is especially cute. It’s funny because they can’t even understand what each other is saying.
Etna and Flonne from Disgaea are also hilarious when together in scenes.