I've heard alot about people selling key loot that has ended up eliminating their chances to complete certain quests.

Just wondering if this was some rumor or if so you mus be careful of what loot you sell.
As it may be possible to reobtain these items through the bazaar it would be a hassle.

I specifically remember that the "Great Serpantskin" you obtain during a hunt is a key item that should not be sold as it may be needed later in the game.

Thoughts and Answers will be appreciated greatly.

don't sell the serpentskin if you want a better reward, but you still can complete that part of the game. (by the way, if i remember, the best reward is a golden amulet, which i didn't even need at that point of the game, i already had a bunch of them) my advice is keep one of each item you get. that way you'll never have to worry if you should or shouldn't have sold anything. after a while you'll see a pattern where you get the same items over and over again and you can sell all of them.

mehh i sell everything early even old weapons just to by a weapon thats just a lil better

i still completed the patient in the desert sidequest even after accidentally selling the great serpentskin....it really only affects what you receive from the quest's completion.

What should I do about all the different kinds of motes you get.
Are they used for magic spells or something? <_<
I just sell em they bulk up my inventory.

Use them as weapons if you want. There should be some battles that you will come across that prevent the use of magic, so you might want to hold on to them.